中山大学中山眼科中心金正京课题组招聘

wenjhuan

金正京教授（Jong Kyong Kim, 韩国籍）于2006年获得美国密歇根州立大学细胞与分子生物学博士学位。完成New England Biolabs、宾夕法尼亚大学和美国国立卫生研究院的博士后研究工作后，她于2013年以中组部青年千人引进人才身份全职加入中山眼科中心国家重点实验室。金教授在肿瘤细胞生物学和表观遗传学等方面的研究成果多次发表于Science、Nucleic Acids Res、Cancer Cell等期刊。

研究方向：

着眼于研究眼科肿瘤形成的遗传学和表观遗传学机制，涉及肿瘤细胞生物学、生物化学和表观遗传学等多个领域。

本课题组的研究方向之一是探索表观遗传调节和染色质修饰因子如何在眼科肿瘤中异常作用以及这种异常会给肿瘤发展带来的影响。通过研究这些蛋白质对肿瘤形成的影响来鉴定和分析它们的作用机制将为眼科肿瘤的表观遗传治疗提供理论基础并推动新药的研发。

本课题组的另一个研究方向是通过分析肿瘤和其他眼科疾病临床样本的基因组和表观遗传信息来明确眼科疾病的发病机理，探索疾病治疗潜在的分子靶标或信号通路。该研究将运用高通量测序技术测定临床样本中全基因组甲基化情况及基因表达水平，然后通过一系列生物化学和分子生物学的方法评估在这些样本中异常表达的潜在靶标或信号通路。


金正京课题组诚聘以下研究人员，有意者请将英文简历发至金正京教授邮箱zoc2013@foxmail.com，并抄送眼科中心人事科邮箱fanxin6@mail.sysu.edu.cn


岗位名称        岗位类别        人数        学历        专业        工作经验        资质或技能要求        期望到岗时间        工作内容
副研究员        研究人员        1        博士        眼科学、肿瘤学、分子生物学或相关专业        已经有3-5年博士后经验        熟悉分子生物学实验、细胞培养、动物实验        2015年        统筹安排实验室事务、与其他科室交流合作、完成科研任务
助理研究员        研究人员        1        博士        眼科学、肿瘤学、分子生物学或相关专业        　        熟悉分子生物学实验、细胞培养、动物实验        2015年        完成科研任务
技术员    技术员         1  硕士    生物或医学专业                      完成实验
副研究员岗位（年薪30万元）具体要求：

The Ocular tumor research group at the Zhongshan Ophthalmic Center (SYSU, Guangzhou) has a senior research scientist position available in the area of tumor biology and epigenetics. A major research focus of the group is directed towards genomic and epigenetic analyses of clinical tumor samples with an aim to understand the ocular disease pathogenesis mechanisms and identification of molecular targets or pathways for potential therapeutic development. The research spans over multidisciplinary fields ranging from cancer cell biology, epigenetics, bioinformatics to clinical translation in collaboration with various research units at Zhongshan Ophthalmic Center.

Qualifications :

- PhD or MD/PhD in tumor biology, epigenetics, or other relevant areas of biomedical sciences (Candidates with more than 3 years' postdoctoral experience preferred)

- Excellent communication skills in both English and Chinese (This is critical)

- Proven history of productive research activities in tumor biology

- Experience in setting up and managing multidisciplinary collaborations

Interested candidates should send their CV in English and a brief description of their research interest and career goal . Potential candidates will be contacted for recommendations and further Inquiries.

Publication list:

Aggarwal P, Vaites L, Kim JK, Mellert H, Gurung B, Nakagawa H, Herlyn M, Hua X, Rustgi A, McMahon SB, and Diehl JA (2010). Nuclear cyclin D1/CDK4 kinase regulates CUL4 expression and triggers neoplastic growth via activation of the PRMT5 methyltransferase. Cancer Cell  18(4):329-40.

Koo SC, Moon BC, Kim JK, Kim CY, Sung SJ, Kim MC, Cho MJ, and Cheong YH (2009) OsBWMK mediates SA-dependent defense responses by activating the transcription factor OsWRKY33. Biochem Biophys Res Commun. 387(2):365-370.

Kim JK and Diehl JA (2009) Nuclear cyclin D1: An oncogenic driver in human cancer. J Cell Physiol. 220(2): 292-296.

Kim JK, Esteve P, Jacobsen SE, and Pradhan S (2009) UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells. Nucleic Acids Res. 37(2): 493-505.

Kim JK, Samaranayake M, and Pradhan S (2009) Epigenetic mechanisms in mammals. Cell Mol. Life Sci. 66(4): 596-612.

Bostick M*, Kim JK*, Esteve P, Clark A., Pradhan, S, and Jacobsen SE (2007) UHRF1 plays a role in maintaining DNA methylation in mammalian cells. Science 317: 1760-1764 ( * : equally contributed to the work; Commented in Ooi SK and Bestor TH (2008) Cytosine methylation: remaining faithful. Curr. Biol.18: R174-6).

Uhal BD, Kim JK, Li X, Molina-Molina M (2007) Angiotensin-TGF-beta1 crosstalk in human idiopathic pulmonary fibrosis: autocrine mechanisms in myofibroblasts and macrophages. Curr. Pharm. Des. 13: 1247-1256.

Quiroz S, Kim JK, Mulrooney SB, and Hausinger RP (2007) “Chaperones of nickel metabolism” in Nickel and Its Surprising Impact in Nature, Vol. 2 of  Metal Ions in Life Sciences; A. Sigel, H. Sigel, R. K. O. Sigel, Eds.; John Wiley & Sons, Ltd., Chichester, UK.

Kim JK, Mulrooney SB, and Hausinger RP (2006) Functional fusion of UreE and UreF urease accessory proteins in Klebsiella aerogenes. J. Bacteriol.188: 8413-8420.

Kim JK, Mulrooney SB, and Hausinger RP (2005) Biosynthesis of active Bacillus subtilis urease in the absence of known urease accessory proteins. J. Bacteriol. 187: 7150-7154.